AACN Certification Practice Test 2026 – Comprehensive Exam Prep

Cullen's sign is primarily associated with pancreatitis. This clinical sign appears as a bluish discoloration around the umbilicus, which can result from the accumulation of blood in the abdominal cavity or peritoneal area, indicative of hemorrhagic conditions. In the case of pancreatitis, particularly when there is necrotizing pancreatitis or severe inflammation, the inflammation can lead to bleeding and subsequent bruising around the peritoneum.

It's important to note that while Cullen's sign may be observed in other conditions as well, such as ectopic pregnancy or abdominal trauma, its association with pancreatitis is particularly noteworthy due to the underlying mechanisms of the disease. The presence of Cullen's sign in a patient with suspected pancreatitis can serve as a clinical clue for healthcare professionals, making it a significant finding in the diagnostic process.