AACN Certification Practice Test 2026 – Comprehensive Exam Prep

For uncomplicated urinary tract infections (UTIs), certain antibiotics are frequently prescribed based on their effectiveness against the common pathogens responsible for these infections. TMP-SMX (Bactrim) DS is particularly well-established for treating uncomplicated UTIs. It combines two antibiotics, trimethoprim and sulfamethoxazole, which work together to inhibit bacterial growth and is often chosen due to its oral bioavailability and effectiveness against E. coli, the primary cause of uncomplicated UTIs.

Amoxicillin also has a role in treating uncomplicated UTIs, particularly in patients who may be pregnant or have allergies to sulfa medications. It is a penicillin-type antibiotic that is generally effective against Gram-positive bacteria and some Gram-negative bacteria. However, some E. coli strains may be resistant to amoxicillin, which can limit its use based on local resistance patterns.

Ciprofloxacin, a fluoroquinolone antibiotic, is effective against a wide range of bacteria, including those that cause UTIs. Although it is effective, fluoroquinolones are typically reserved for more complicated cases due to concerns over antibiotic resistance and potential side effects.

Given that TMP-SMX, amoxicillin, and ciprofloxacin can all be prescribed for uncomplicated UTIs depending on the